Bosentan is surely an inducer of CYP3A and CYP2C9. Therefore plasma concentrations of medicine metabolized by these two isozymes will be decreased when bosentan is coadministered. Bosentan and Ro 48-5033 are already shown to get substrates with the human organic and natural anion transporting polypeptides OATP1B1 and OATP1B3.22 Ciclosporin A https://waylonmstuv.blogzag.com/70541673/bosentan-things-to-know-before-you-buy