Below, we display that conolidine, a natural analgesic alkaloid used in regular Chinese medicine, targets ACKR3, thus providing further proof of the correlation between ACKR3 and suffering modulation and opening alternate therapeutic avenues for the treatment of Persistent ache. CONOCB2, referred to as “In excess of-the-counter Morphine” by GDR https://proleviate.com/block-pain-receptors-with-conolidine/