Environmental or self-antigens and homotypic interactions set off BCR and Toll-like receptor (TLR) signaling, amplifying the reaction of CLL cells to other alerts through the microenvironment and expanding the activation of anti-apoptotic and proliferation pathways.31,32 Genomic studies have recognized recurrent mutations in genes regulating tumor mobile-microenvironment interactions,... https://alexandrei207zgp3.dm-blog.com/profile