And lastly, clonidine improves neuraxial opioids and, together with fentanyl, interacts within an additive manner, which often can decrease the dose of each component by 60% for postoperative analgesia. Clonidine treats superior hypertension by stimulating αtwo receptors in the brainstem, which decreases peripheral vascular resistance, reducing blood pressure level. https://businessbookmark.com/story5291013/onolidine-an-overview